Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree (Garcinia mangostana). It is a yellow. The anticancer activity is induced by xanthones such as alpha-, beta-, and gamma-mangostin which are major constituents of the pericarp of mangosteen fruits. In order to obtain the biological active compound, α-mangostin, from the traditional native mangosteen (Garcinia mangostana L.), an extraction.

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B Membranes incubated with the anti-Bcl-2 antibody.


Mangostim pMAPK in the ischaemic heart: White arrows indicate chromatin condensation in YD cells. Membranes were incubated with anti-caspase-3, anti-caspase-9 and anti-PARP antibodies. CA Cancer J Clin. Statistical significance was determined by the Dunnett’s t-test.

Chemical constituents of Garcinia mangostana. On day 22, mice were sacrificed and tumors excised. Initiator caspases are activated by death signals to further activate the effector caspases Cancer is one of the most life-threatening diseases worldwide, and the incidence and mortality of cancer in Korea have continuously increased due to various acquired risk factors, including a Western diet and environmental factors 1. The percentage of apoptotic cells in the untreated control group was Apoptosis, otherwise known as programmed cell death, is characterized by a number of well-defined features, such as condensation allha fragmentation of chromatin, internucleosomal DNA cleavage, caspase activation and the qlpha of phosphatidylserine from the inner to the outer leaflet of the plasma membrane A portion of the tumor was embedded in paraffin and used for TUNEL assays and immunohistochemical analysis.


A comparative study of effects of aversectin C abamectin and ivermectin on apoptosis of rat thymo-cytes induced by radiation and dexamethasone.

Cancer statistics in Korea: Anthocyanins induce cell cycle perturbations and apoptosis in different human cell lines. Sign up for eToc alerts. A marked difference between the treated and control groups was observed beginning on day 8 following treatment Fig.

Mangostin – Wikipedia

Moreover, the number of viable cells decreased in a concentration-dependent manner. Oral cancer poses a risk of invasion to adjacent organs and a higher possibility mangostn metastatic relapse. Both caspase-3 and -9 were activated, as evidenced by the increased levels of the respective cleaved forms, as well as PARP segmentation Fig. International Journal of Molecular Medicine. The absorbance of the solutions at nm was determined using a microplate reader Bio-Rad Laboratories, Inc.

April Volume 37 Issue 4. Apoptosis and the cell cycle. International Journal of Molecular Medicine 37, no. A Membranes incubated with the anti-Bax antibody.

The cells were then washed twice and resuspended in RPMI medium. Proliferation, cell cycle and apoptosis in alphs. Thus, as regards the development of particular anticancer drugs and preventive medications, the extent that a substance affects cancer cell cycle progression should be identified. The expression of c-myc also decreased. In other words, an increase in the proportion of sub-G1 cells reflects an increase in apoptosis. Bcl-2 family proteins control membrane permeability and are located in the mitochondrial membrane or move to the mitochondrial membrane to induce apoptotic cell death Pharmacological effects of xanthones as cardiovascular protective agents.


To identify Ki protein expression, immunohistochemistry was performed as described in the Material and methods. DAPI staining was utilized to observe the cells by fluorescence microscopy. All animal mangoetin were performed following the approval of the Institutional Animal Care and Use Committee according to manyostin guidelines of Kongju National University.

In some studies, it was reported that several naturally derived substances induce apoptosis and inhibit cancer cell growth 21 —