Carcinoma Mucoepidermoide de Glándulas Salivales Intraoral: Factores Clínicos y Patológicos e Inmunoexpresión de c-erbB-2 en 29 Casos. Vanessa Fátima. Abstract. AVILA, Rodolfo Esteban et al. Mucoepidermoid Carcinoma of Salivary Glands: Histological and Inmunohistochemical Prognostic Factors. Publisher: El propósito de este estudio es presentar la casuística del carcinoma mucoepidermoide de glándulas salivales de pacientes diagnosticados en el.

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Review of the literature and clinicopathological analysis of 18 patients. However, there are few articles with a significative number of cases Lopes et al. Cytoplasmic expression of c-erbB2 in non-small cell lung cancers. The palate was the most commonly affected site, with 21 cases Mucoepidermoid carcinoma MEC is the most common malignant neoplasm of major and minor salivary glands Lopes et al, Despite the small sample studied our results demonstrated no association among c-erbB-2 expression and demographic or histological grades of MEC.

The broad age range observed in our series supports that reported in literature.

Carcinoma mucoepidermoide

Cytoplasmic expression was also observed but not considered in this study as reported in diverse salivary gland tumors Kernohan et al. However, its prognostic value should be validated with clinical studies and survival analyses. However, many studies found that benign and malignant salivary gland neoplasms with evidence of myoepithelial lineage do not overexpress c-erbB-2 protein which support the view that this growth receptor is not involved in their pathogenesis Rosa et al.

Tumors were stratified into three groups: Salivary glands ; ucoepidermoid carcinoma ; Prognostic factors. The clinicopathologic features and results of log rank tests for clinical variables are shown in tables 1 and 2respectively. Histological classification of salivary gland tumours.

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Carcinoma mucoepidermoide de glándulas salivales en Brasil: relación clinicopatológica

Coexpression of p53 and c-erbB-2 proteins is associated with histological type, tumour stage, and cell proliferation in malignant salivary gland tumours.

Briefly, 4 um sections were dewaxed in xylene and hydrated with graded ethanol. Casilla D Temuco – Chile Tel.: Data regarding the positivity for c-erbB-2 on salivary gland tumors are very variable. Microscopically, most intraoral MEC were classified as low grade of maligancy 27cases – The Kaplan-Meier method was used to plot survival curves with the log rank test for analysis of cumulative survival rates. Surgical resection was performed in all patients.

Although MEC has been described as a radioresistant tumor, postoperative radiotherapy has been associated with decreased recurrence in some reports. Saliavles oral pathologists reviewed all cases to histopathologically classify these tumors according to the protocol published by Brandwein and others 10which classifies tumors into low Grade Iintermediate Grade II or high Carcino,a III grades.

Complementary galndulas to compare carbohydrates of the normal salivary glands must be carried out because subtle alterations in tumor cells glycosylation can influence their biological behavior.

Clinicopathologic and immunohistochemical study of intraoral mucoepidermoid carcinoma. Low grade tumors seem to arise more often in minor salivary glands, which according to some authors are detected at earlier stages, probably due to the carciboma aggressive growth in addition to a better visible tumor site. Mucoepidermoid carcinoma of the salivary glands in Brazil: Data concerning survival recurrence and metastasis were evaluated.

Salivary gland tumors in children and adolescents: Mucoepidermoid carcinoma of the major salivary glands: Due to the singularity and diverse histology of these tumors, prognostic factors have been difficult to elucidate.


Carcinoma mucoepidermoide

There were no statistically significant differences for any analyzed variable affecting OS curves. Otolaryngol Head Neck Surg. MEC was prevalent in the female gender We undertook this study to analyze the histological grade and proliferative potential as prognostic factors, important to guide the treatment and design recommendations, in a series of 13 patients who were treated for MEC of principal and accessory salivary glands between and Its intracellular component has a tyrosine kinase activity, whereas the extracellular domain may act as a growth factor receptor because of its considerable homology with epidemial growth factor receptor Nguyen et al.

Immunoexpression of c-erbB-2 and p53 in benign and malignant salivary neoplasms with myoepithelial differentiation. MEC is the most common malignancy of salivary glands and presents a diverse age distribution Auclair et al; Lopes et al.

The 5 and year overall survival rates were both Unlike other studies that used this same grading system, 4,13 the results demonstrate a balance in distribution among the three tumor grades subtypes. This study aimed to investigate prognostic factors that may affect salivaless in patients with a primary diagnosis of head and neck mucoepidermoid carcinomas.

Carcinoma of the parotid and submandibular glands a study of survival in patients.

Complete resection was defined as a histological report of negative margins of more than 10 mm.